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姚琳
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 姚琳

职称/职位: LIN YAO   副研究员   所属院校:3044am永利集团官网vip,3044am永利集团官网vip导师类别: 博士生导师、硕士生导师   个人简述:姚琳,女,1977年5月出生,辽宁沈阳人,汉族,博士研究生导师。现任3044am永利集团官网vip副研究员,中国微循环学会痰瘀专业委员会委员和中国中西医结合会微循环专业委员会青年委员,Journal of Cardiovascular Disease Research和 Editor Board of World Science Publisher的编辑。

教育、工作经历

教育背景:
2000年毕业于中央民族大学,获学士学位。
2004年毕业于沈阳药科大学,获硕士学位。
2008年毕业于南方医科大学,获博士学位。
工作经历:
2008年至2015年,美国乔治亚医学院,药理毒理系,博士后。
2015年至今, 3044am永利集团官网vip,3044am永利集团官网vip,副研究员。

研究方向

糖尿病所致血管损伤的分子机制及新靶点,精氨酸酶在血管内皮损伤中的作用,及中药化学成分在心血管疾病的预防和治疗机制研究

科研及教学课题

  1. 国家自然科学基金,项目批准号:31600937,项目名称: 内皮细胞精氨酸酶活性改变在2型糖尿病血管损伤中的作用及机制研究。(主持)
    国家自然科学基金面上项目项目批准号:31571041,中间神经元ErBb4激活促NO生成机制及其介导的神经分裂症发病机制研究(第二)

 

代表性成绩:

   ATVB Travel Award for Young Investigators, AHA’s Scientific Sessions 2011, Orlando, FL.        2.Young Scientist Travel Award of the Pharmacology and Experimental Therapeutics, Experimental Biology 2011, Washington, DC.

    代表性论文论著  
  • 1. Lv H, Zhu C, Wu R, Ni H, Lian J, Xu Y, Xia Y, Shi G, Li Z, Caldwell RB, Caldwell RW, Yao L#, Chen Y#.Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress,Journal of Psychiatric Research,2019 Apr 23;114:55-66.
    2. Xiaofei An, Maoxiang Zhang, Tian Lu, SiSi Zhou, Yongjun Chen, Lin Yao#, Xiao-Shen-Formula, a Traditional Chinese Medicine, Improves Glomerular Hyper-filtration in Diabetic Nephropathy via Inhibiting Arginase Activation and Heparanase Expression, Frontiers in Physiology-Vascular Physiology. 2018, 9(26),01195.
    3. Lin Yao, Anil Bhatta, Zhimin Xu, Haroldo A. Toque, JijunChen,Reem T. Atawia, AbdelrahmanFouda, ZsoltBagi, Rudolf Lucas, Ruth B. Caldwell and R. William Caldwell, Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase. Cardiovascular Reasearch. 2017,113,1664-1676.
    4. Lin Yao, Anil Bhatta, Zhimin Xu, Jijun Chen2, HaroldoA.Toque,Yongjun Chen, Yimin Xu, ZsoltBagi,Rudolf Lucas, YuqingHuo, Ruth B. Caldwell3 and R. William Caldwell, Obesity-induced vascular inflammation involves elevated arginase activity Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase.  American  Journal of Physicology. 2017, 313: R560-R571.
    5. Yao L, Chandra S, Toque HA, Bhatta A, Rojas M, Caldwell RB, Caldwell RW., Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout, Cardiovasc Res. 2013 Mar 1;97(3): 509-19.
    6. Lin Yao, Maritza J. Romero, Haroldo A. Toque et al, The Role of RhoA/Rho Kinase Pathway in Endothelial Dysfunction., Journal of Cardiovascular Disease Research, 2010, 1(4):165-170.
    7. Yao Lin, Deng Kang-ying, Luo Jia-bo, Comparative Study of Antiasthmatic and Antitussive effect between Ephedrine and Methylephedrine. Journal of Chinese Medicinal Materials. 2008, 31(3): 416.
    8. Yao Lin, Deng Kang-ying, Luo Jia-bo, Comparative Study of Antiasthmatic and Antitussive effect between Ephedrine and Total Alkaloid of Ephedra..Pharmacology and Clinics of Chinese MateriaMedica, 2008, 24(2): 18.
    9. Yao Lin, Luo Jia-bo, Preparation and in vitro dissolution of cinnamon oil sustained-release capsules. Journal of Southern Medical University, 2008, 28(1): 52.
    10. Yao Lin, Pang Xiu-juan, Cheng Lan et al. Preparation of CVB-D pellets. Journal of Shenyang Pharmaceutical University, 2005, 4: 248.

    专利

    1、桂皮醛的新用途,国家发明专利,专利公开号:CN109044997A.
    2、青蒿衍生物在制备抗癫痫药物中的应用,国家发明专利已受理,专利申请号:201811306343.5;国际发明专利已受理,专利申请号:PCT/CN2018/121596

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