代表性科研及教学课题
1. 广东省科技厅项目,2016A020226031, 毛冬青三萜皂苷在血管内皮细胞的摄取转运特征和抑制炎性损伤的作用机制及物质基础研究,2016/07~2019/06,30万元,在研,主持。
2. 广州市科技厅一般科学研究项目, 201607010334, 基于“心与小肠相表里”的毛冬青IPTS抗冠状动脉粥样硬化作用机制及药效物质基础研究, 2016.04.01~2019.03.12,20万, 在研, 主持
3. 广东省教育厅“创新强校工程”科研项目,2016KTSCX019,基于药动学和组学技术探索毛冬青IPTS抗CHD作用机制及物质基础。主持,2017.01.01~2018.12.31,在研 Foundation of Guangdong Educational Committee
4. 高水平大学建设校级青年项目:张蕾毛冬青三萜皂苷在血管内皮细胞的PK-PD结合模型和抑制其炎性损伤的作用机制及物质基础研究。主持,2017.01.01~2018.12.31,在研 4. 国家自然科学基金面上项目,81473540, 黄连-吴茱萸药对改变肠道菌群结构与抗溃疡性结肠炎作用的相关性及其机制研究, 2015/01~2018/12,75万元,在研,参加(排名第2)
5. 3044am永利集团官网vip“青年英才培养工程”项目,QNYC201240103,毛冬青IPTS部位质量控制方法和药物代谢动力学研究. 2013/01-2016/12,20万,已结题,主持。
6. 广州市科技计划项目(珠江科技新星),2011J2200047,基于胃肠道生物转化的冬青属三萜皂降解产物及其抗血栓活性研究,2012/01-2014/12,30万元,已结题,参加(排名第4)。
7.国家自然科学基金青年基金项目, 30901953, 基于胃肠转运和生理药动学模型探索中药复方组分配伍相关作用规律及机制, 2010/01-2012/12,22万元,已结题,主持
8. 国家教育部新教师基金项目,20094425120001,基于胃肠转运和生理药动学模型探索中药复方组分配伍相关作用规律及机制, 2010/01-2012/12,3.6万元,已结题,主持
9. 国家自然科学基金青年基金项目,30901954,从冬青属植物中寻找作用于P2Y12受体新靶点的抗血栓活性成分,2010/01-2012/12,20万元,已结题,参加(排名第2)
10. 国家自然科学基金青年基金项目,30901898,基于声音传感的仿生指中医脉象检测基础理论研究,2010/01-2012/12,20万元,已结题,参加(排名第5)
11. 国家自然科学基金面上项目,30873428,大黄黄连泻心汤主要化学成分成分与生理药动学研究,2009/01-2011/12,30万,已结题,参加(排名第3)
12. 广东省自然科学基金项目,9451010701003203,毛冬青三萜皂苷成分代谢产物及其抗血栓作用机制的研究,2010/01-2012/12,3万元,已结题,参加(排名第3)
13. 3044am永利集团官网vip教育研究课题:中外中药学高等教育实践教学的比较研究(JYKY0817,主持,2009.01.01~2010.12.31,已结题)
14. 3044am永利集团官网vip创新实验项目:基于过程信息管理系统的苦参黄酮类成分高通量分离模式研究(08CX17,主持,2009.01.01~2010.12.31,已结题)
代表性文章
[1] Mingjuan Zhu, Pinqing Wei, Qian Peng,Shengying qin, Yuan Zhou, Ren Zhang,Chenchen Zhu*,Lei Zhang*. Simultaneous qualitative and quantitative evaluation of Toddalia asiatica root by using HPLC-DAD and UPLC-QTOF-MS/MS. Phytochemical Analysis,2018,1-18, Doi: 10.1002/pca.2802
[2] Huan Yi, Jie Zhou, Xueying Shang, Zhongxiang Zhao, Qian Peng, Miangjuan Zhu, Chenchen Zhu, Chaozhan Lin, Qide Liu, Qiongfeng Liao, Leizhang*. Multi-component analysis of Ilex Kudingcha C.J. Tseng by a single marker quantification method and chemometric discrimination of HPLC fingerprints. Molecules, 2018,23, 854; doi:10.3390/molecules23140854
[3] Jie Zhou, Huan Yi, Zhong-Xiang Zhao, Xue-YingShang, Ming-Juan Zhu, Guo-Jun Kuang, Chen-Chen Zhu, Lei Zhang*. Simultaneous Qualitative and Quantitative Evaluation of Ilex kudingcha C.J.Tseng by using UPLC and UHPLC-qTOF-MS/MS, Journal of Pharmaceutical and Biomedical Analysis https://doi.org/10.1016/j.jpba.2018.02.037
[4] 朱明娟,邝国俊,高巍,易欢,赵钟祥,周园,韦品清,廖琼峰,张蕾*. 毛冬青HPLC-UV指纹图谱与化学模式识别. 中国中药杂志,2018,43(6): 1182-1187
[5] ZQ Feng, J Zhou, XY Shang, GJ Kuang, J Han, LP Lu, Lei Zhang*. Comparative research on stability of baicalin and baicalein administrated in monomer and total flavonoid fraction form of Radix scutellariae in biological fluids in vitro. Pharmaceutical Biology, 2017, 55(1): 1177-1184 (SCI).
[6] XS Li, J Zhou, GJ Kuang, XY Shang, XL Liu, L Tong*, Zhang Lei*. The study on the fingerpint and qualitative analysis of characteristic volatile constituents in Xihuang Pill by GC/GC-MS. Current Analytical Chemistry, 2017, 13 (6): 231-241.
[7] Guojun Kuang, Huan Yi, Mingjuan Zhu, Jie Zhou, Xueying Shang, Zhongxiang Zhao, Chenchen Zhu, Qiongfeng Liao, Shixia Guan, Lei Zhang*. Study of absorption characteristics of the total saponins from Radix Ilicis Pubescentis in an in situ single-pass intestinal perfusion (SPIP) Rat Model by using ultra performance liquid chromatography (UPLC). Molecules, 2017 Nov 1;22(11). pii: E1867. doi: 10.3390/molecules22111867.
[8] 周杰,商雪莹,佟玲,刘晓琳,张蕾*. HPLC-ELSD法同时测定西黄丸中6种乳香酸类成分. 中草药,2017, 48(4): 706-709
[9] 周杰,商雪莹,佟玲,刘晓琳,张蕾*. 西黄丸HPLC-ELSD指纹图谱研究. 中草药,2017,48(11):2219-2224
[10] 周杰,商雪莹,杜慧琴,卢丽萍,张蕾.三物黄芩汤组分(群)配伍在大鼠肝微粒体赋予模型中的相互作用. 中成药,2017,39(9):1813-1819
[11] GJ Kuang, J Zhou, MC Yao, QL Tan, LK Qi, JH Liang, Y Li, ZX Zhao*, L Zhang*. Systematic study on QAMS method for simultaneously determination of triterpenoid saponins in Ilex Pubescens by HPLC and UPLC. Analytical Methods, 2015, 7, 6579-6587 (SCI)
[12] Tingting Li, Lei Zhang*, Ling Tong, Qiongfeng Liao. High-throughput salting-out assisted homogeneous liquid-liquid extraction with acetonitrile for determination of baicalin in rat plasma with high -performanceliquid chromatography. Biomedical Chromatography, 2014, 28(5): 648-653 (SCI)
13] Tingting Li,ZhiqiangFeng,MeicunYao,Lei Zhang*. Comparative Pharmacokinetic and Tissue Distribution Study of Baicalin, Baicalein, Wogonoside, Wogonin and Oroxylin A after Oral Administration of Component Compatibility of Sanwu-Huangqin-Tang and Total Flavonoids Fractions of Radix Scutellariae to Rats. Analytical Methods, 2014, 6,5799-5807 (SCI)
[14] Huiling Huo, Tingting Li, Lei zhang*. pKa determination of oxysophocarpine by reversed-phase high performance liquid chromatography. Springerplus. 2013, 2(1): 270-278.